NFL preseason week 1 NFL odds are posted at top online books such as Bovada and MyBookie Yes, Joe Duffy of OffshoreInsiders.com remains the top preseason handicapper in history and will have his famed preseason primer here at JoeDuffy.Net.
| Thur, Aug 8 | SP/RL | TOTAL | |
| PRESEASON – WEEK 1 – (Preseason Limits Available on Game Day) | |||
| 7:05 PM | |||
| 251 | Jets | -1½ (-105) | 33½ (-110) |
| 252 | Giants | +1½ (-115) | 33½ (-110) |
| 7:05 PM | |||
| 253 | Colts | PK (-109) | 35 (-105) |
| 254 | Bills | PK (-111) | 35 (-115) |
| 7:35 PM | |||
| 255 | Patriots | -1½ (-110) | 38 (-110) |
| 256 | Lions | +1½ (-110) | 38 (-110) |
| 7:35 PM | |||
| 257 | Redskins | +2 (-121) | 35½ (-105) |
| 258 | Browns | -2 (EV) | 35½ (-115) |
| 7:35 PM | |||
| 259 | Falcons | +3 (-105) | 36 (-102) |
| 260 | Dolphins | -3 (-115) | 36 (-119) |
| 7:35 PM | |||
| 261 | Titans | +3½ (-121) | 37 (-105) |
| 262 | Eagles | -3½ (EV) | 37 (-115) |
| 7:35 PM | |||
| 263 | Jaguars | +4 (-105) | 33½ (-110) |
| 264 | Ravens | -4 (-115) | 33½ (-110) |
| 8:05 PM | |||
| 265 | Texans | +2½ (-110) | 36 (-110) |
| 266 | Packers | -2½ (-110) | 36 (-110) |
| 8:05 PM | |||
| 267 | Panthers | +3 (-101) | 38 (-110) |
| 268 | Bears | -3 (-120) | 38 (-110) |
| 10:05 PM | |||
| 271 | Broncos | +2 (-121) | 36 (-110) |
| 272 | Seahawks | -2 (EV) | 36 (-110) |
| 10:05 PM | |||
| 269 | Chargers | +2 (-105) | 35 (-113) |
| 270 | Cardinals | -2 (-115) | 35 (-107) |
| Friday, 9th August 2019 | SP/RL | TOTAL | |
| PRESEASON – WEEK 1 – (Preseason Limits Available on Game Day) | |||
| 7:35 PM | |||
| 273 | Buccaneers | +2½ (-110) | 37 (-110) |
| 274 | Steelers | -2½ (-110) | 37 (-110) |
| 8:05 PM | |||
| 275 | Vikings | +3 (-126) | 37 (-110) |
| 276 | Saints | -3 (+105) | 37 (-110) |
| Saturday, 10th August 2019 | SP/RL | TOTAL | |
| PRESEASON – WEEK 1 – (Preseason Limits Available on Game Day) | |||
| 8:05 PM | |||
| 277 | Bengals | +3½ (-121) | 36½ (-110) |
| 278 | Chiefs | -3½ (EV) | 36½ (-110) |
| 8:05 PM | |||
| 279 | Rams | +4 (-115) | 36 (-110) |
| 280 | Raiders | -4 (-105) | 36 (-110) |
| 9:05 PM | |||
| 281 | Cowboys | +4 (-111) | 36 (-110) |
| 282 | 49ers | -4 (-109) | 36 (-110) |